Frequency-dependent effects of aconitine and veratridine on membrane currents in the crayfish giant axon.
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چکیده
منابع مشابه
Effects of harmaline on membrane excitability and ATPase activity of the crayfish giant axon.
Effects of harmaline on excitability of crayfish giant axon in relation to effects on Na,K-ATP activity were investigated and the findings were compared with relative data on ouabain. Exposure of the axon to harmaline in doses over 0.5 mM resulted in a dose-dependent reduction of the action potential. Harmaline of 2.5 mM produced a complete blockade of the action potential with a slight decreas...
متن کاملNIK-247 blocks voltage-dependent ionic currents in crayfish axon.
NIK-247 (9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]-quinoline hydrochloride hydrate), an acetylcholinesterase inhibitor, is structurally related to 4-aminopyridine (AP). Its effects on ionic currents were examined in the artificial node of the crayfish axon under voltage-clamp. When applied externally, NIK-247 reversibly suppressed both inward and outward currents. Effects on K currents wer...
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ژورنال
عنوان ژورنال: The Japanese Journal of Physiology
سال: 1985
ISSN: 1881-1396,0021-521X
DOI: 10.2170/jjphysiol.35.463